Terry Graham retired on Sept. 30, 2012. > View retirement reception photos
Plant-microbe interactions; biochemistry and molecular genetics of disease resistance; plant natural products chemistry.
My research focuses on the molecular biology of signal perception and signal transduction in local and systemic induced plant disease resistance.
The induction of disease resistance in plants in response to infection by a pathogen involves a complex cascade of molecular signals and events. They culminate in the expression of the defense responses which provide protection against the pathogen. The deployment of these responses involves multiple cell types, each of which plays a different role.
Our research involves a variety of techniques and frequent interaction with other scientists in the areas of plant pathology, biochemistry, molecular biology and cell biology. We are interested in defining and characterizing the molecular, cellular and genetic nature of the cell-to-cell and intracellular signaling processes that regulate the defense reactions of different cells.
My research is primarily focused on these aspects in soybean. Emphasis is currently on development of globally useful software for liquid chromatography-mass spectrum (LC-MS) based metabolomics for plant research. In our own research, we are then applying this software to constitutive and induced soybean disease and insect resistance. We are also linking the metabolomics analyses in a systems biology approach to genomic and transcriptomic data to identify the key metabolic genes involved in resistance.
- B.S Biochemistry, Summa cum laude, Pennsylvania State University
- M.S. Biochemistry, Purdue University
- Ph.D. Biochemistry, Purdue University
- Post-Doctoral Plant Pathology, University of Wisconsin (with Luis Sequeira)
Please contact firstname.lastname@example.org for details on current projects.
View > Longer list of publications
- Jiye Cheng, Chunhua Yuan, Terrence L. Graham. 2011. Potential defense-related prenylated isoflavones in lactofen-induced soybean. Phytochemistry 72: 875–881.
- Pan L, Sinden MR, Kennedy AH, Chai H, Watson LE, Graham TL, Kinghorn AD. 2009. Bioactive constituents of Helianthus tuberosus (Jerusalem artichoke). Phytochemistry Letters. Vol. 2: 15-18.
- Graham, T. L., Graham, L., and Yu, O. 2008. Book chapter, "Genomics of Soybean Secondary Product Metabolism" in Genetics and Genomics of Soybean. Stacey G, ed. Springer Verlag, NY, pp. 211-242.
- Pan, L., Sinden, M., Kennedy, A., Chai, H., Watson, L., Graham, T. L., and Kinghorn, A. 2008. Bioactive constituents of Helianthus tuberosus (Jerusalem artichoke). Phytochemistry Letters. DOI information: 10.1016/j.phytol.2008.10.003.
- Graham, T. L., Graham, L., Subramanian, S., and Yu, O. 2007. RNAi silencing of genes for elicitation or biosynthesis of 5-deoxyisoflavonoids suppresses race specific resistance and hypersensitive cell death in Phytophthora sojae infected tissues. Plant Physiology 144:728-740.
- Graham, MY, Weidner J, Wheeler K, Pelow ML, Graham TL. 2003. Pathogenesis- Related Protein Gene Activation in Soybean by Wounding and the Phytophthora sojae Cell Wall Glucan Elicitor, Physiological and Molecular Plant Pathology 63:141-149.
- Landini, S., Graham, M. Y. and Graham, T. L. 2003. Lactofen induces isoflavone accumulation and glyceollin elicitation competency in soybean. Phytochemistry, Special Issue on Metabolomics, 62:865-874.
- Park, D.S., Graham, M. Y., Landini, S. and Graham,T.L. 2002. Induced distal defense potentiation against Phytophthora sojae in soybean. Physiol. Molec. Plant Pathol., 60:293-310.
- Park, D.S., Graham, M. Y. and Graham, T. L. 2001. Identification of soybean elicitation competency factor, CF-1, as the soybean Kunitz trypsin inhibitor. Physiol. Molec. Plant Pathol. 59:265-273.
- Hsieh, M. C. and T. L. Graham. 2001. Partial purification and characterization of a soybean ?-glucosidase with high specific activity for isoflavone conjugates. Phytochemistry 58:995-1005.
- Abbasi, P.A., Graham, M. Y. and Graham, T. L. 2001. Effects of soybean genotype on the glyceollin elicitation competency of cotyledon tissues to Phytophthora sojae glucan elicitors. Physiol. Molec. Plant Pathol. 59:95-105.
- 1977-1979 Project Leader, Host-Pathogen Project, Monsanto Company
- 1979-1982 Senior Research Group Leader, Stress Biochemistry Group
- 1982-1984 Monsanto Company Science Fellow, Biological Control, Monsanto Company
- 1984-1986 Research Manager, Cellular and Molecular Biology, Monsanto Company
- 1986-1992 Assistant Professor, Department of Plant Pathology, Ohio State University
- 1992-2002 Associate Professor, Department of Plant Pathology, Ohio State University
- 1996-2000 Associate Chair, Department of Plant Pathology, Ohio State University
- 2000-2002 Chairman, The Ohio Plant Biotechnology Consortium
- 2010-2011 Interim Associate Chair, Department of Plant Pathology, Ohio State University