Dr. Guo-Liang Wang

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Dr. Guo-Liang Wang

Associate Chair, Endowed Professor of Plant Protection and OSU Distinguished Scholar

wang.620@osu.edu

(614) 292-9280

Office:

483B Kottman Hall, Columbus

Professional Information

Degrees & Credentials:

PhD Univ of the Philippines Los Baños and Intl Rice Research Institute (IRRI), Philippines

MSc Fujian Agricultural University, Fuzhou, China

BSc Hunan Agricultural University, Changsha, China

Biography:

Molecular Biology of Plant-Microbe Interactions and Plant Immunity

View Publications under the "Works" tab.

Lab website
Wang Lab for Plant Disease Resistance and Functional Genomics

News

2019 > Wang Receives the Ohio State University's Distinguished Scholar Award
2016 > Wang is one of four Ohio State faculty in 2016 class of AAAS Fellows
2013 :> Wang Honored with OARDC Senior Faculty Research Award
2012 > Wang Named American Phytopathological Society Fellow

Research Areas

A. Unraveling the molecular mechanisms underlying host resistance to pathogens using genetic and genomic approaches.

We aim to understand the intricate dynamics of plant-pathogen interactions and the signal transduction pathways triggering immune responses. We analyze the functions of effector proteins from fungal pathogens and determine how these effectors target host proteins for defense suppression. Additionally, we strive to characterize immune receptors and investigate how they recognize fungal effectors and activate defense responses using both genetic and genomic approaches. Our long-term goal is to develop crop plants for disease resistance, aiming to reduce reliance on environmentally damaging pesticides.

B. Application of cell-penetrating peptides (CPPs) for sustainable agriculture.

CPPs are short peptides capable of enhancing the delivery of various cargos (proteins, DNA, and RNA) into cells. While extensively employed in delivering pharmacological therapeutics for human diseases, their applications in plants have been relatively limited. Recently, our lab has demonstrated that the new CPP MTD4 significantly enhances the delivery of defense activator proteins into plant cells. We are developing innovative strategies to apply MTD4 fusion proteins to control plant pathogens via foliar application, thereby contributing to sustainable crop production.

Teaching and Outreach

Principles of Molecular Plant Microbe Interactions (PLNTPTH 5003); 2 credits; Spring semesters

Agricultural Genomics (PLNTPTH 7003.01); 2 credits; Spring semesters, odd numbered years

Professional Experience

Current: Endowed Professor of Plant Protection and Associate Chair
Professor, Department of Plant Pathology, Ohio State University, Columbus, Ohio, 7/2008-present
Acting Associate Chair,Department of Plant Pathology, Ohio State University, Columbus, Ohio, 12/2015-1/2019
Associate Professor, Department of Plant Pathology, Ohio State University, Columbus, Ohio, 5/2004-7/2008
Assistant Professor, Department of Plant Pathology, Ohio State University, Columbus, 10/1999-7/2004
Senior Scientist and Principal Investigator, Institute of Molecular Agrobiology, The National University of Singapore, 8/1996-9/1999
Postdoctoral Research Associate, University of California at Davis, 8/1993-8/1996
Postdoctoral Research Associate, Texas A&M University, 6/1992-8/1993Selected Publications

Awards and Honors

Fellow, American Association for the Advancement of Science (AAAS), Oct., 2016
Distinguished Senior Faculty Research Award, OARDC, College of Food, Agric. & Env. Sci., Ohio State University; 2013
Fellow, American Phytopathological Society (aps), August, 2012
William E. Krauss Director's Award for Excellence in Graduate Research Mentorship from OARDC, OSU, 4/2009
Research Award of Merit, Gamma Sigma Delta, Honor Society of Agriculture/OSU, 4/2007
The Syngenta Award of the American Phytopathology Society, 8/2006
OARDC Distinguished Junior Faculty Research Award, 5/2005
DuPont Young Professor Award (8/2000)

Works

Publications can be found on the following sites:

Research Gate > www.researchgate.net/profile/Guo-Liang_Wang

Google Scholar > scholar.google.com/citations?user=m7pBX58AAAAJ&hl=en

Selected papers

You, X., S. Zhu, H. Sheng, Z. Liu, D. Wang, M. Wang, X. Xu, F. He, H. Fang, F. Zhang, D. Wang, Z. Hao, R. Wang, Y. Xiao, J. Wan, G. L. Wang and Y. Ning (2023). "The rice 2 peroxisomal receptor PEX5 negatively regulates resistance to rice blast fungus Magnaporthe oryzae." Cell Rep 42(10): 113315.
You, X., Y. Ning and G. L. Wang (2023). "Editing a rice CDP-DAG synthase confers broadspectrum resistance." Trends Plant Sci 28(12): 1344-1346.
Xu, Y., L. Bai, M. Liu, Y. Liu, S. Peng, P. Hu, D. Wang, Q. Liu, S. Yan, L. Gao, X. Wang, Y. Ning, S. Zuo, W. Zheng, S. Liu, W. Xiang, G. L. Wang and H. Kang (2023). "Identification of two novel rice S genes through combination of association and transcription analyses with gene-editing technology." Plant Biotechnol J. (8):1628-1641, doi: 10.1111/pbi.14064
Wang, R., G. L. Wang and Y. Ning (2023). "Harnessing nanobodies to expand the recognition spectrum of plant NLRs for diverse pathogens." aBIOTECH 4(3): 272-276.
Wang, L., G. Xu, L. Li, M. Ruan, A. Bennion, G. L. Wang, R. Li and S. Qu (2023). "The OsBDR1-MPK3 module negatively regulates blast resistance by suppressing the jasmonate signaling and terpenoid biosynthesis pathway." Proc Natl Acad Sci U S A 120(13): e2211102120.
Shi, X., Y. Xiong, K. Zhang, Y. Zhang, J. Zhang, L. Zhang, Y. Xiao, G. L. Wang and W. Liu (2023). "The ANIP1-OsWRKY62 module regulates both basal defense and Pi9-mediated immunity against Magnaporthe oryzae in rice." Mol Plant 16(4): 739-755.
Li, M., W. Li, M. Zhao, Z. Li, G.-L. Wang, W. Liu and C. Liang (2023). "Transcriptome analysis reveals a lncRNA-miRNA-mRNA regulatory network in OsRpp30-mediated disease resistance in rice." BMC Genomics 24(1): 643.
Chen, S., Cao, H., Huang, B., Zheng, X., Liang, K., Wang, G.L. and Sun, X. (2022) The WRKY10-VQ8 module safely and effectively regulates rice thermotolerance. Plant Cell Environ, 45, 2126-2144. DOI: 10.1111/pce.14329
Ding, B., Xie, H., Zhang, K., Li, H., Gao, Y., Zhang, J., Xu, B., Peng, L., Yang, G., Wang, G.L. et al. (2022) Nuclear EPL-HAM complex is essential for the development of chloroplasts. J Genet Genomics, 49, 1165-1168. DOI: 10.1016/j.jgg.2022.04.006
Fang, H., Zhang, F., Zhang, C., Wang, D., Shen, S., He, F., Tao, H., Wang, R., Wang, M., Wang, D. et al. (2022) Function of hydroxycinnamoyl transferases for the biosynthesis of phenolamides in rice resistance to Magnaporthe oryzae. J Genet Genomics, 49, 776-786. DOI: 10.1016/j.jgg.2022.02.008
Gentzel, I.N., Ohlson, E.W., Redinbaugh, M.G. and Wang, G.-L. (2022) VIGE: virus-induced genome editing for improving abiotic and biotic stress traits in plants. Stress Biology, 2, 2. DOI: 10.1007/s44154-021-00026-x
Hao, Z., Tian, J., Fang, H., Fang, L., Xu, X., He, F., Li, S., Xie, W., Du, Q., You, X. et al. (2022) A VQ-motif-containing protein fine-tunes rice immunity and growth by a hierarchical regulatory mechanism. Cell Rep, 40, 111235. DOI: 10.1016/j.celrep.2022.111235
Paul, S.K., Mahmud, N.U., Gupta, D.R., Rani, K., Kang, H., Wang, G.-L., Jankuloski, L. and Islam, T. (2022) Oryzae pathotype of Magnaporthe oryzae can cause typical blast disease symptoms on both leaves and spikes of wheat under a growth room condition. Phytopathology Research, 4, 9. DOI: 10.1186/s42483-022-00114-4
Wang, J., Xu, G., Ning, Y., Wang, X. and Wang, G.L. (2022) Mitochondrial functions in plant immunity. Trends Plant Sci, 27, 1063-1076. DOI: 10.1016/j.tplants.2022.04.007
Wang, R., Xu, X., Wang, G.L. and Ning, Y. (2022) Ubiquitination of susceptibility proteins modulates rice broad-spectrum resistance. Trends Plant Sci, 27, 322-324. DOI: 10.1016/j.tplants.2021.12.012
Wang, R., You, X., Zhang, C., Fang, H., Wang, M., Zhang, F., Kang, H., Xu, X., Liu, Z., Wang, J. et al. (2022) An ORFeome of rice E3 ubiquitin ligases for global analysis of the ubiquitination interactome. Genome Biol, 23, 154. DOI: 10.1186/s13059-022-02717-8
You, X., Zhang, F., Liu, Z., Wang, M., Xu, X., He, F., Wang, D., Wang, R., Wang, Y., Wang, G. et al. (2022) Rice catalase OsCATC is degraded by E3 ligase APIP6 to negatively regulate immunity. Plant Physiol, 190, 1095-1099. DOI: 10.1093/plphys/kiac317
Zhang, F., Fang, H., Wang, M., He, F., Tao, H., Wang, R., Long, J., Wang, J., Wang, G.L. and Ning, Y. (2022) APIP5 functions as a transcription factor and an RNA-binding protein to modulate cell death and immunity in rice. Nucleic Acids Res, 50, 5064-5079. DOI: 10.1093/nar/gkac316
Wang, J., Wang, R., Fang, H., Zhang, C., Zhang, F., Hao, Z., You, X., Shi, X., Park, C.H., Hua, K., He, F., Bellizzi, M., Xuan Vo, K.T., Jeon, J.S., Ning, Y., and Wang, G.L. (2021). Two VOZ transcription factors link an E3 ligase and an NLR immune receptor to modulate immunity in rice. Mol Plant 14, 253-266.
Wang, D., Liu, Z., Xiao, Y.H., Liu, X.L., Chen, Y., Zhang, Z., Kang, H.X., Wang, X.L., Jiang, S., Peng, S.S., Tan, X.Q., Zhang, D.Y., Liu, Y., Wang, G.L., and Li, C.G. (2021). Association Mapping and Functional Analysis of Rice Cold Tolerance QTLs at the Bud Burst Stage. Rice 14.
Tao, H., Shi, X.T., He, F., Wang, D., Xiao, N., Fang, H., Wang, R.Y., Zhang, F., Wang, M., Li, A.H., Liu, X.L., Wang, G.L., and Ning, Y. (2021). Engineering broad-spectrum disease-resistant rice by editing multiple susceptibility genes. J Integr Plant Biol 63, 1639-1648.
Tang, B.Z., Liu, C.Y., Li, Z.Q., Zhang, X.X., Zhou, S.Q., Wang, G.L., Chen, X.L., and Liu, W.D. (2021). Multilayer regulatory landscape during pattern-triggered immunity in rice. Plant Biotechnology Journal 19, 2629-2645.
Shen, S.Q., Peng, M., Fang, H., Wang, Z.X., Zhou, S., Jing, X.Y., Zhang, M., Yang, C.K., Guo, H., Li, Y.F., Lei, L., Shi, Y.H., Sun, Y.Y., Liu, X.Q., Xu, C.P., Tohge, T., Yuan, M., Fernie, A.R., Ning, Y., Wang, G.L., and Luo, J. (2021). An Oryza-specific hydroxycinnamoyl tyramine gene cluster contributes to enhanced disease resistance. Sci Bull 66, 2369-2380.
Mutiga, S.K., Rotich, F., Were, V.M., Kimani, J.M., Mwongera, D.T., Mgonja, E., Onaga, G., Konate, K., Razanaboahirana, C., Bigirimana, J., Ndayiragije, A., Gichuhi, E., Yanoria, M.J., Otipa, M., Wasilwa, L., Ouedraogo, I., Mitchell, T., Wang, G.L., Correll, J.C., and Talbot, N.J. (2021). Integrated Strategies for Durable Rice Blast Resistance in Sub-Saharan Africa. Plant Dis 105, 2749-2770.
Mahesh, H.B., Shirke, M.D., Wang, G.L., and Gowda, M. (2021). In planta transcriptome analysis reveals tissue-specific expression of pathogenicity genes and microRNAs during rice-Magnaporthe interactions. Genomics 113, 265-275.
Li, W., Xiong, Y., Lai, L.B., Zhang, K., Li, Z., Kang, H., Dai, L., Gopalan, V., Wang, G.L., and Liu, W. (2021). The rice RNase P protein subunit Rpp30 confers broad-spectrum resistance to fungal and bacterial pathogens. Plant Biotechnol J.
Lee, D.Y., Jeon, J., Kim, K.T., Cheong, K., Song, H., Choi, G., Ko, J., Opiyo, S.O., Correll, J.C., Zuo, S.M., Madhav, S., Wang, G.L., and Lee, Y.H. (2021). Comparative genome analyses of four rice-infecting Rhizoctonia solani isolates reveal extensive enrichment of homogalacturonan modification genes. Bmc Genomics 22.
Kang, H.X., Peng, Y., Hua, K.Y., Deng, Y.F., Bellizzi, M., Gupta, D.R., Mahmud, N.U., Urashima, A.S., Paul, S.K., Peterson, G., Zhou, Y.L., Zhou, X.P., Islam, M.T., and Wang, G.L. (2021). Rapid Detection of Wheat Blast Pathogen Magnaporthe oryzae Triticum Pathotype Using Genome-Specific Primers and Cas12a-mediated Technology. Engineering 7, 1326-1335.
Gao, M.J., He, Y., Yin, X., Zhong, X.B., Yan, B.X., Wu, Y., Chen, J., Li, X.Y., Zhai, K.R., Huang, Y.F., Gong, X.Y., Chang, H.Z., Xie, S.H., Liu, J.Y., Yue, J.X., Xu, J.L., Zhang, G.Q., Deng, Y.W., Wang, E.T., Tharreau, D., Wang, G.L., Yang, W.B., and He, Z.H. (2021). Ca2+ sensor-mediated ROS scavenging suppresses rice immunity and is exploited by a fungal effector. Cell 184, 5391-.
Feng, Z., Yuan, M., Zou, J., Wu, L.-B., Wei, L., Chen, T., Zhou, N., Xue, W., Zhang, Y., Chen, Z., Hu, K., Wang, G.-L., Liu, W., Pan, X., and Zuo, S. (2021). Development of marker-free rice with stable and high resistance to rice black-streaked dwarf virus disease through RNA interference. Plant Biotechnology Journal 19, 212-214.
Fang, H., Shen, S.Q., Wang, D., Zhang, F., Zhang, C.Y., Wang, Z.X., Zhou, Q.Q., Wang, R.Y., Tao, H., He, F., Yang, C.K., Peng, M., Jing, X.Y., Hao, Z.Y., Liu, X.L., Luo, J., Wang, G.L., and Ning, Y.S. (2021). A monocot-specific hydroxycinnamoylputrescine gene cluster contributes to immunity and cell death in rice. Sci Bull 66, 2381-2393.
Fan, J., Bai, P., Ning, Y., Wang, J., Shi, X., Xiong, Y., Zhang, K., He, F., Zhang, C., Wang, R., Meng, X., Zhou, J., Wang, M., Shirsekar, G., Park, C., Bellizzi, M., Liu, W., Jeon, J., Xia, Y., Shan, L., Wang, G.L*. 2018. The Monocot-Specific Receptor-like Kinase SDS2 Controls Cell Death and Immunity in Rice. Cell Host Microbe. 23(4):498-510.e5. doi: 10.1016/j.
Wang GL*, Valent B. 2017. Durable resistance to rice blast. Science. 3;355(6328):906-907. doi: 10.1126/science.aam9517.
Wang R, Ning Y, Shi X, He F, Zhang C, Fan J, Jiang N, Zhang Y, Zhang T, Hu Y, Bellizzi M, Wang GL*. 2016. Immunity to Rice Blast Disease by Suppression of Effector-Triggered Necrosis. Current Biology. 26:2399-2411. doi: 10.1016/j.cub.2016.06.072.
Park CH, Shirsekar G, Bellizzi M, Chen S, Songkumarn P, Xie X, Ning Y, Zhou Z, Suttiviriya P, Umemura K, and Wang G.L*. 2016. The E3 ligase APIP10 connects the effector AvrPiz-t to the NLR receptor Piz-t in rice. PLOS Pathogens, 12(3): e1005529. doi:10.1371/journal.ppat.1005529.
Liu J, Park CH, He F, Nagano M, Wang M, Bellizzi M, Zhang K, Zeng X, Liu W, Ning Y, Kawano Y, Wang GL*. 201 The RhoGAP SPIN6 associates with SPL11 and OsRac1 and negatively regulates programmed cell death and innate immunity in rice. PLOS Pathogens 11(2):e1004629. doi: 10.1371/journal.ppat.1004629.
Liu, W. Liu, J. Triplett, L Leach, J. and Wang GL*. 2014. Novel insights into the rice innate immunity against bacterial and fungal pathogens. Annual Review of Phytopathology 52:213-41.
Park, C.H., Chen, S., Shirsekar, G., Zhou, B., Khang, C.H., Songkumarn, P., Afzal, A.J., Ning, Y., Wang, R., Bellizzi, M., Valent, B. & Wang, G.L*. (2012). The Magnaporthe oryzae Effector AvrPiz-t Targets the RING E3 Ubiquitin Ligase APIP6 to Suppress Pathogen-Associated Molecular Pattern-Triggered Immunity in Rice. Plant Cell, 24: 4748–4762
Ding, B., Bellizzi Mdel, R., Ning, Y., Meyers, B.C. & Wang, G.L*. (2012). HDT701, a Histone H4 Deacetylase, Negatively Regulates Plant Innate Immunity by Modulating Histone H4 Acetylation of Defense-Related Genes in Rice. Plant Cell 24, 3783-94
Ning, Y., Jantasuriyarat, C., Zhao, Q., Zhang, H., Chen, S., Liu, J., Liu, L., Tang, S., Park, C.H., Wang, X., Liu, X., Dai, L., Xie, Q., and Wang, G.L*. (2011). The SINA E3 Ligase OsDIS1 Negatively Regulates Drought Response in Rice. Plant Physiology 157, 242-255.
La, H., Ding, B., Mishra, G.P., Zhou, B., Yang, H., Bellizzi Mdel, R., Chen, S., Meyers, B.C., Peng, Z., Zhu, J.K., and Wang, G.L*. (2011). A 5-methylcytosine DNA glycosylase/lyase demethylates the retrotransposon Tos17 and promotes its transposition in rice. Proc Natl Acad Sci USA 108, 15498-15503.

*Corresponding author

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