Professor

Current site: http://www.oardc.ohio-state.edu/soydefense

Graham Lab (Coming soon)

Cell-to-Cell Signaling and Signal Transduction in Disease Resistance

Dr. Graham's research focuses on the molecular biology of signal perception and signal transduction in local and systemic induced plant disease resistance. The induction of disease resistance in plants in response to infection by a pathogen involves a complex cascade of molecular signals and events. They culminate in the expression of the defense responses which provide protection against the pathogen. The deployment of these responses involves multiple cell types, each of which plays a different role. We are interested in defining and characterizing the molecular, cellular and genetic nature of the cell-to-cell and intracellular signaling processes that regulate the defense reactions of different cells. Dr. Graham's research is primarily focused on these aspects in soybean. Our research involves a variety of techniques and frequent interaction with other scientists in the areas of plant pathology, biochemistry, molecular biology and cell biology. Emphasis is currently on utilizing the soybean EST database for functional genomics, including the development of DNA macroarrays for analysis of gene expression. Other projects include the development of novel chemical and genetic strategies for systemic, broad-spectrum and durable disease resistance in soybean.

Recent Review Articles Covering our Research

(Please contact me at graham.1@osu.edu for more details on current projects):

• Graham, T. L. 1995. Cellular biochemistry of phenylpropanoid responses of Soybean to infection by Phytophthora sojae. pp.85-116. In, Handbook of Phytoalexin Metabolism and Activity, M. Daniel and R. P. Purkayastha, eds., Marcel Dekker, NY.

• Graham, T. L. and Graham, M. Y. 1999. Role of hypersensitive cell death in conditioning elicitation competency and defense potentiation. Physiol. Molec. Plant Pathology, 55: 13-20.

• Graham, T. L. and Graham, M. Y. 1999. Defense potentiation and competency: redox conditioning effects of salicylic acid and genistein. Molecular Plant Microbe Interactions, Volume 5, Stacey, G. and Keen, N. T., eds., in press.

• Graham, T. L. 2000. The biosynthesis and distribution of phytoestrogens and their roles in plant defense, signal transduction and cell-to-cell signaling. J. Medicinal Food, 2: 93-97.

Contact Information

Terry Graham
Office: 477C Kottman Hall

The Ohio State University
Department of Plant Pathology
201 Kottman Hall
2021 Coffey Road
Columbus, Ohio 43210-1087

Phone: (614) 292-1375
FAX: (614) 292-4455
Email: graham.1@osu.edu