Professor Lab web site: http://www.oardc.ohio-state.edu/soydefense Plant-microbe interactions; biochemistry and molecular genetics of disease resistance; plant natural products chemistry. Terry Graham co-teaches Plant Microbe Interactions (PLNTPTH 602) offered spring quarters and serves as the department's Graduate Studies Chair.

View a highlight piece on Terry Graham's OARDC research in natural products chemistry > Metabolite Mining (pdf)

Cell-to-Cell Signaling and Signal Transduction in Disease Resistance

Dr. Graham's research focuses on the molecular biology of signal perception and signal transduction in local and systemic induced plant disease resistance. The induction of disease resistance in plants in response to infection by a pathogen involves a complex cascade of molecular signals and events. They culminate in the expression of the defense responses which provide protection against the pathogen. The deployment of these responses involves multiple cell types, each of which plays a different role. We are interested in defining and characterizing the molecular, cellular and genetic nature of the cell-to-cell and intracellular signaling processes that regulate the defense reactions of different cells. Dr. Graham's research is primarily focused on these aspects in soybean. Our research involves a variety of techniques and frequent interaction with other scientists in the areas of plant pathology, biochemistry, molecular biology and cell biology. Emphasis is currently on utilizing the soybean EST database for functional genomics, including the development of DNA macroarrays for analysis of gene expression. Other projects include the development of novel chemical and genetic strategies for systemic, broad-spectrum and durable disease resistance in soybean.

Recent Publications

Please contact graham.1@osu.edu for details on current projects.

Graham, T. L., Graham, L., and Yu, O. 2008.  Book chapter, "Genomics of Soybean Secondary Product Metabolism" in Genetics and Genomics of Soybean. Stacey G, ed. Springer Verlag, NY, pp. 211-242.

Pan, L., Sinden, M., Kennedy, A., Chai, H., Watson, L., Graham, T. L., and Kinghorn, A. 2008. Bioactive constituents of Helianthus tuberosus (Jerusalem artichoke). Phytochemistry Letters. DOI information: 10.1016/j.phytol.2008.10.003.

Graham, T. L., Graham, L., Subramanian, S., and Yu, O. 2007. RNAi silencing of genes for elicitation or biosynthesis of 5-deoxyisoflavonoids suppresses race specific resistance and hypersensitive cell death in Phytophthora sojae infected tissues. Plant Physiology 144:728-740.

Graham, MY, Weidner J, Wheeler K, Pelow ML, Graham TL. 2003. Pathogenesis-  Related Protein Gene Activation in Soybean by Wounding and the Phytophthora sojae Cell Wall Glucan Elicitor, Physiological and Molecular Plant Pathology 63:141-149.

Landini, S., Graham, M. Y. and Graham, T. L.  2003. Lactofen induces isoflavone accumulation and glyceollin elicitation competency in soybean.  Phytochemistry, Special Issue on Metabolomics, 62:865-874.

Park, D.S., Graham, M. Y., Landini, S. and Graham,T.L. 2002. Induced distal defense potentiation against Phytophthora sojae in soybean. Physiol. Molec. Plant Pathol., 60:293-310.

Park, D.S., Graham, M. Y. and Graham, T. L. 2001. Identification of soybean elicitation competency factor, CF-1, as the soybean Kunitz trypsin inhibitor. Physiol. Molec. Plant Pathol. 59:265-273.

Hsieh, M. C. and T. L. Graham. 2001.  Partial purification and characterization of a soybean β-glucosidase with high specific activity for isoflavone conjugates. Phytochemistry 58:995-1005.

Abbasi, P.A., Graham, M. Y. and Graham, T. L. 2001. Effects of soybean genotype on the glyceollin elicitation competency of cotyledon tissues to Phytophthora sojae glucan elicitors.  Physiol. Molec. Plant Pathol. 59:95-105.

Graham, T. L. 1995. Cellular biochemistry of phenylpropanoid responses of Soybean to infection by Phytophthora sojae. pp.85-116. In, Handbook of Phytoalexin Metabolism and Activity, M. Daniel and R. P. Purkayastha, eds., Marcel Dekker, NY.

Graham, T. L. and Graham, M. Y. 1999. Role of hypersensitive cell death in conditioning elicitation competency and defense potentiation. Physiol. Molec. Plant Pathology, 55: 13-20.

Graham, T. L. and Graham, M. Y. 1999. Defense potentiation and competency: redox conditioning effects of salicylic acid and genistein. Molecular Plant Microbe Interactions, Volume 5, Stacey, G. and Keen, N. T., eds., in press.

Graham, T. L. 2000. The biosynthesis and distribution of phytoestrogens and their roles in plant defense, signal transduction and cell-to-cell signaling. J. Medicinal Food, 2: 93-97.

Contact Information

Terry Graham
Office: 477C Kottman Hall

The Ohio State University
Department of Plant Pathology
201 Kottman Hall
2021 Coffey Road
Columbus, Ohio 43210-1087

Phone: (614) 292-1375
FAX: (614) 292-4455
Email: graham.1@osu.edu